Download A Guide to Human Gene Therapy by Roland W. Herzog, Sergei Zolotukhin PDF

By Roland W. Herzog, Sergei Zolotukhin

Ever because the beginning of molecular biology, the tantalizing threat of treating illness at its genetic roots has turn into more and more possible. Gene treatment even though nonetheless in its infancy is still one of many most well-liked parts of study in medication. Its procedure makes use of a gene move car (''vector'') to convey healing DNA or RNA to cells of the physique with a purpose to rectify the disorder that's inflicting the disorder. profitable treatments were stated in people lately similar to remedies in boys with critical immune deficiencies. furthermore, gene treatment concepts are being tailored in different biomedical laboratories to procure novel remedies for a number of illnesses and to review simple organic points of sickness. Correction of disorder in animal experiences, is progressively gaining flooring, highlighting the significant capability of gene remedy within the clinical occupation.

This ebook will hide issues which are on the leading edge of biomedical learn reminiscent of RNA interference, viral and non-viral gene move structures, therapy of hematological ailments and problems of the critical fearful process. prime specialists at the respective vector or illness will give a contribution the person chapters and clarify state-of-the-art applied sciences. It additionally offers a extensive review of crucial gene move vectors and such a lot greatly studied objective ailments. This complete consultant is accordingly a must-read for someone within the biotechnology, biomedical or scientific industries looking to additional their wisdom within the zone of human gene remedy

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Mendiratta SK, et al. (2000). Combination of interleukin 12 and interferon alpha gene therapy induces a synergistic antitumor response against colon and renal cell carcinoma. Hum Gene Ther 11: 1851–1862. 51. Kaushik A (2001). Leuvectin Vical Inc. Curr Opin Investig Drugs 2: 976–981. 52. Ho HK, et al. (2004). Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Circulation 109: 1314–1319. 53. Grossman PM, et al. (2007). Results from a phase II multicenter, double-blind placebocontrolled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease.

Mendiratta SK, et al. (2000). Combination of interleukin 12 and interferon alpha gene therapy induces a synergistic antitumor response against colon and renal cell carcinoma. Hum Gene Ther 11: 1851–1862. 51. Kaushik A (2001). Leuvectin Vical Inc. Curr Opin Investig Drugs 2: 976–981. 52. Ho HK, et al. (2004). Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Circulation 109: 1314–1319. 53. Grossman PM, et al. (2007). Results from a phase II multicenter, double-blind placebocontrolled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease.

Proc Natl Acad Sci USA 84: 7413–7417. 17 May 4, 2010 11:0 SPI-B903 9in x 6in b903-ch01 A Guide to Human Gene Therapy 4. Felgner PL, Ringold GM (1989). Cationic liposome-mediated transfection. Nature 337: 387–388. 5. Wolff JA, et al. (1990). Direct gene transfer into mouse muscle in vivo. Science 247: 1465–1468. 6. Nabel GJ, et al. (1996). Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes. Proc Natl Acad Sci USA 93: 15388–15393.

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